Production of Hydrogel-Based Curcumin-Loaded O/W Suspoemulsions

Curcumin is a biopharmaceutical classification system (BCS) class IV substance with many potential therapeutic effects. However, like other BCS active pharmaceutical ingredients, complex formulations are needed to guarantee sufficiently high bioavailability. A not-so-well-known delivery suspoemulsion (SE). SEs emulsions crystalline API in continuous or dispersed phases. This study aimed produce curcumin-loaded o/w suspoemulsions the particle oil phase for, e.g., encapsulation triggered release The particles need be smaller than emulsion droplet size attain efficiencies (EE) phase. Sonofragmentation and bead milling were tested for their ability these nanocrystals different dispersion media. It was discovered that production miglyol best fit application of crystals SEs. Around 85% (by volume) produced about 5 µm. In contrast, only 23% sonofragmentated below diameter those droplets. oily suspension then used successfully hydrogel-based suspoemulsions. second part this study, we investigated methods determining efficiency, but none accurately satisfactorily resolved efficiency. Finally, could not macroscopically distinguished from one another physically stable. summary, showed stable produced.